What Are The Factors Influencing How Drugs Affect The Body?

1. Medicine dose: the effect of the medicine increases with the increase in the quantity of medicine up to the RECEPTOR SATURATION POINT

1. Number of receptors that the receptors can have very different levels. They differ from one tissue to another and therefore mediate biological reactions at different levels.
   • Example:Beta-1 receptors are more concentrated in the heart; Therefore, beta-1 agonists have a greater effect on the heart. Beta-2 receptors are most expressed in the bronchioles of the lungs and in the arteries of the skeletal muscles; Therefore, beta-2 agonists produce the greatest effect in these tissues and organs.
2. Pathological conditions:Pathological conditions can be effects Pharmacology of the drug
   • Example: The pharmacokinetics of a drug changes dramatically in a patient with chronic kidney disease
     • The volume Digoxin drug distribution decreases when a person has chronic kidney disease [CKD]. Clearance also decreases, leading to an increase in the half-life of digoxin, meaning that a patient with chronic kidney disease actually requires a lower dose than a patient with a normally functioning kidney to achieve safe and effective levels of digoxin.
3. Efficacy/Intrinsic activity of the drug:ability to activate or block a receptor: maximum effect that a drug can produce independently of the dose that can cause
4. Potency/affinity of the drug:speed of binding and release of the drug to the receptor: amount of drug necessary to produce a specific effectcause: Affinity of the drug for the receptor:
   See below: The more effective the drug is, the faster it binds to its receptor (forward rate) and the slower it is absorbed by its released receptor (back ).

Efficacy versus potency: As the drug's effectiveness increases, so does the maximum biological response it can produce. Efficacy cannot be altered by increasing the dose beyond that which produces a maximal response, as this is an intrinsic property of the medicinal product. Although potency is also an intrinsic property of a specific drug, drug effects can be increased by using higher doses because potency is related to the rate of drug receptor binding and dissociation, while potency is related to the resulting biological response. .

a drug is therefore clinically more important than the

POTENCY because the dose of the drug can be manipulated to produce the desired response in the case of a low-potency drug, but a low-potency drug cannot be manipulated at the same time.

What are the factors influencing drug use?

An individual's current circumstance incorporates various impacts, from loved ones to monetary status and general personal satisfaction. Factors, for example, peer pressure, physical and sexual maltreatment, early openness to medications, stress, and parental direction can incredibly influence an individual's probability of medication use and fixation

What is the way drugs influence the body?

Drugs impede the manner in which neurons send, get, and process signals by means of synapses. A few medications, like weed and heroin, can enact neurons on the grounds that their substance structure impersonates that of a characteristic synapse in the body. This permits the medications to join onto and initiate the neurons.